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The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish

27 Jun 2025

Abstract excerpt

The transcription factors TFEB and TFE3 modulate expression of lysosomal, autophagic, and metabolic genes to restore energy and cellular homeostasis in response to a variety of stress conditions. Since their role during vertebrate development is less characterized, we used CRISPR/Cas9 to deplete tfeb, tfe3a, and tfe3b in zebrafish. The simultaneous lack of these genes compromised embryo survival during early...

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PMID: 40577485
DOI: 10.1371/journal.pgen.1011754

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