Article

FAM83F regulates canonical Wnt signalling through an interaction with CK1α

2020-05-26

Abstract excerpt

<h4>ABSTRACT</h4> The function of the FAM83F protein, like the functions of many members of the FAM83 family, is poorly understood. Here we show that injection of Fam83f mRNA into Xenopus embryos causes axis duplication, a phenotype indicative of enhanced Wnt signalling. Consistent with this, overexpression of FAM83F activates Wnt signalling, whilst ablation of FAM83F from human colorectal cancer (CRC) cells att...

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Literature Corpus work: bbddaee1-3e86-5eca-a338-0d15ec4792ca
DOI: 10.1101/2020.05.25.114504

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