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Article

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 2024

Valcikova Barbora, Vadovicova Natalia, Smolkova Karolina, Zacpalova Magdalena, Krejci Pavel, Lee Shannon, Rauch Jens, Kolch Walter, von Kriegsheim Alexander, Dorotikova Anna, Andrysik Zdenek, Vichova Rachel, Vacek Ondrej, Soucek Karel, Uldrijan Stjepan

Abstract excerpt

The eIF4F translation initiation complex plays a critical role in melanoma resistance to clinical BRAF and MEK inhibitors. In this study, we uncover a function of eIF4F in the negative regulation of the rat sarcoma (RAS)/rapidly accelerated fibrosarcoma (RAF)/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) signaling pathway. We...

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Share to Cell Line, Tumor
Share to Eukaryotic Initiation Factor-4E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Signal-Regulated MAP Kinases

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Share to Proto-Oncogene Proteins B-raf

Source

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Identifiers

PMID: 39436655
DOI: 10.1073/pnas.2321305121
PMCID: PMC11536119

Genes

BRAF
NRAS
DUSP6
EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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