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Article

IL6 and WNK2 polymorphisms and prognosis in patients with intracerebral hemorrhage receiving edaravone.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2025

Zhang Yu-Peng, Wang Sai, Yao Tian-Xing, Zou Xue-Lun, Li Si, Chen Lei, Zhang Xiang-Bin, Chen Jun-You, Zeng Yi, Zhang Le

Abstract excerpt

OBJECTIVE: Edaravone is utilized in intra-cerebral hemorrhage (ICH) patients for years, while personalized variances were observed in clinic. To explore the precision medicine strategy for Edaravone, this study investigated the association between genetic polymorphisms and Edaravone efficacy in ICH patients. METHODS: We genotyped 7 SNPs in 4 potential genes, including COL4A2, TNF, WNK2 and IL6, from the...

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PMID: 39433142
DOI: 10.1016/j.jstrokecerebrovasdis.2024.108095

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