Article
Genetic variants in CETP increase risk of intracerebral hemorrhage.
Annals of neurology - 1 Nov 2016
Anderson Christopher D, Falcone Guido J, Phuah Chia-Ling, Radmanesh Farid, Brouwers H Bart, Battey Thomas W K, Biffi Alessandro, Peloso Gina M, Liu Dajiang J, Ayres Alison M, Goldstein Joshua N, Viswanathan Anand, Greenberg Steven M, Selim Magdy, Meschia James F, Brown Devin L, Worrall Bradford B, Silliman Scott L, Tirschwell David L, Flaherty Matthew L, Kraft Peter, Jagiella Jeremiasz M, Schmidt Helena, Hansen Björn M, Jimenez-Conde Jordi, Giralt-Steinhauer Eva, Elosua Roberto, Cuadrado-Godia Elisa, Soriano Carolina, van Nieuwenhuizen Koen M, Klijn Catharina J M, Rannikmae Kristiina, Samarasekera Neshika, Al-Shahi Salman Rustam, Sudlow Catherine L, Deary Ian J, Morotti Andrea, Pezzini Alessandro, Pera Joanna, Urbanik Andrzej, Pichler Alexander, Enzinger Christian, Norrving Bo, Montaner Joan, Fernandez-Cadenas Israel, Delgado Pilar, Roquer Jaume, Lindgren Arne, Slowik Agnieszka, Schmidt Reinhold, Kidwell Chelsea S, Kittner Steven J, Waddy Salina P, Langefeld Carl D, Abecasis Goncalo, Willer Cristen J, Kathiresan Sekar, Woo Daniel, Rosand Jonathan
Abstract excerpt
OBJECTIVE: In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. Here, we test the hypothesis that...
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