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ALK1 Signaling in Human Cardiac Progenitor Cells Promotes a Pro-angiogenic Secretome

1 Jan 2024

Abstract excerpt

Pro-angiogenic paracrine/autocrine signaling impacts myocardial repair in cell-based therapies. Activin A receptor-like type 1 (ACVRL1, ALK1) signaling plays a pivotal role in cardiovascular development and maintenance, but its importance in human-derived therapeutic cardiac cells is not well understood. Here, we isolated a subpopulation of human highly proliferative cells (hHiPCs) from adult epicardial tissue...

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PMID: 39430425
DOI: 10.33696/signaling.5.119

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