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Interaction between polymorphisms in TNF-⍺ and RANKL genes is associated with the development of persistent apical periodontitis, in Brazilian subjects.

Archives of oral biology - 1 Jan 2025

Petean Igor Bassi Ferreira, Silva-Sousa Alice Corrêa, Marañón-Vásquez Guido Artemio, Paula-Silva Francisco Wanderley Garcia de, Küchler Erika Calvano, Antunes Leonardo Santos, Segato Raquel Assed Bezerra, Silva Lea Assed Bezerra da, Mazzi-Chaves Jardel Francisco, Lopes-Olhê Fabiane Carneiro, Sousa-Neto Manoel Damião

Abstract excerpt

OBJECTIVES: To investigate the association between genetic polymorphisms in suppressor of cytokine signaling-1 (SOCS-1), tumor necrosis factor-⍺ (TNF-α) and its receptors 1 and 2 (TNFRSF1A and TNFRSF1B), receptor activator of nuclear factor kappa-b (RANK), receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin (OPG), and persistent apical periodontitis (PAP). METHODS: Patients with pulp...

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PMID: 39426312
DOI: 10.1016/j.archoralbio.2024.106106

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