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Exploring Persistent Apical Periodontitis in Humans: Integrative Genetic, Histological and Microbiological Perspectives for Translational Research.

International endodontic journal - 1 Mar 2026

Petean Igor Bassi Ferreira, Silva-Sousa Alice Corrêa, de Camargo Rafael Verardino, Silva-Sousa Yara Terezinha Corrêa, Basso Fernanda Gonçalves, Pitondo-Silva André, de Paula-Silva Francisco Wanderley Garcia, Kuchler Erika Calvano, da Silva Raquel Assed Bezerra, da Silva Lea Assed Bezerra, Mazzi-Chaves Jardel Francisco, Lopes-Olhê Fabiane Carneiro, Sousa-Neto Manoel Damião

Abstract excerpt

AIM: To evaluate the impact of polymorphisms in SOCS-1, TNF-α and RANKL on gene expression of RANK, RANKL, TNFRSF1, SOCS-1, IL-10, IL-1β and TNF-α, and to evaluate the histopathological, immunohistochemical and microbiological aspects of persistent apical periodontitis (PAP) after root canal treatment (RCT) in Brazilian individuals. METHODOLOGY: Patients with pulp necrosis and apical periodontitis at the time of...

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Interleukin-10
Interleukin-1beta
RANK Ligand
Real-Time Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor Activator of Nuclear Factor-kappa B

Suppressor of Cytokine Signaling 1 Protein

Translational Research, Biomedical

Tumor Necrosis Factor-alpha

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Identifiers

PMID: 41388504
DOI: 10.1111/iej.70070
PMCID: PMC12884208

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Exploring Persistent Apical Periodontitis in Humans: Integrative Genetic, Histological and Microbiological Perspectives for Translational Research.PMID 41388504Read ↗

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