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Article

Investigation of Genetic Polymorphisms in BMP2, BMP4, SMAD6, and RUNX2 and Persistent Apical Periodontitis.

Journal of endodontics - 1 Feb 2021

Küchler Erika Calvano, Hannegraf Natascha Douat, Lara Rafaela Mariana, Reis Caio Luiz Bitencourt, Oliveira Daniela Silva Barroso de, Mazzi-Chaves Jardel Francisco, Ribeiro Andrades Kesly Mary, Lima Lorena Ferreira de, Salles Alessandro Guimarães, Antunes Livia Azeredo Alves, Sousa-Neto Manoel Damião, Antunes Leonardo Santos, Baratto-Filho Flares

Abstract excerpt

INTRODUCTION: This study aimed to evaluate the interplay among single-nucleotide polymorphisms (SNPs) in the encoding genes BMP2, BMP4, SMAD6, and RUNX2 in persistent apical periodontitis (PAP). METHODS: In this multicentric study, 272 patients diagnosed with pulp necrosis with apical periodontitis before root canal therapy who attended regular follow-up visits for at least 1 year were screened. Periapical...

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PMID: 33245975
DOI: 10.1016/j.joen.2020.11.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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