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Article

SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer

18 Oct 2024

Abstract excerpt

New FOXM1-specific inhibitors with the potential to be used for therapeutic purposes are under extensive research. We hypothesized that deacetylation of FOXM1 would decrease protein expression, thus providing novel therapeutic management of colon cancers. Immunostaining was used to determine FOXM1 and SIRT2 expressions in human colon cancer tissue microarrays (n = 90) from Stage I to Stage IV. SIRT2-FOXM1...

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PMID: 39425454
DOI: 10.1002/jbt.70018

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