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Article

Function of the SIRT1 protein deacetylase in cancer.

Biotechnology journal - 1 Nov 2007

Stünkel Walter, Peh Bee Keow, Tan Yong Cheng, Nayagam Vasantha M, Wang Xukun, Salto-Tellez Manuel, Ni BinHui, Entzeroth Michael, Wood Jeanette

Abstract excerpt

The NAD(+)-dependent protein deacetylase SIRT1 is linked to cellular survival pathways by virtue of keeping the tumor suppressor gene p53 and members of the forkhead transcription factor family deacetylated. To validate SIRT1 as a therapeutic anti-cancer target, we performed immunohistochemistry...

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Source

Identifiers

PMID: 17806102
DOI: 10.1002/biot.200700087

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17806102-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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