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Article

Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma

11 Dec 2017

Abstract excerpt

Sirt family has been reported playing a significant role in the cancer development, especial its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating tumor epithelial-mesenchymal transition (EMT) and metastasis in colon cancer has not been explored. Here, the mass spectrometry and co-immunoprecipitation assays were utilized to detect that SIRT6 was physically associated with...

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PMID: 29227545
DOI: 10.1002/jcb.26539

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