Article
Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales.
Nature communications - 18 Oct 2024
Graf Fabrice E, Goodman Richard N, Gallichan Sarah, Forrest Sally, Picton-Barlow Esther, Fraser Alice J, Phan Minh-Duy, Mphasa Madalitso, Hubbard Alasdair T M, Musicha Patrick, Schembri Mark A, Roberts Adam P, Edwards Thomas, Lewis Joseph M, Feasey Nicholas A
Abstract excerpt
Infections with Enterobacterales (E) are increasingly difficult to treat due to antimicrobial resistance. After ceftriaxone replaced chloramphenicol (CHL) as empiric therapy for suspected sepsis in Malawi in 2004, extended-spectrum beta-lactamase (ESBL)-E rapidly emerged. Concurrently, resistance to CHL in Escherichia coli and Klebsiella spp. decreased, raising the possibility of CHL re-introduction. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.