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Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase producing Enterobacterales

2023-11-16

Abstract excerpt

Infections with Enterobacterales (E) are increasingly difficult to treat due to antimicrobial resistance. After ceftriaxone replaced chloramphenicol (CHL) as empiric therapy for suspected sepsis in Malawi in 2004, ESBL-E rapidly emerged. Concurrently, resistance to CHL in Escherichia coli and Klebsiella spp. decreased, raising the possibility of CHL re-introduction. However, many phenotypically susceptible isola...

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Literature Corpus work
00957dd9-79e0-5914-b384-de34c5daf177
DOI
10.1101/2023.11.16.567242
Open publication

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Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase producing EnterobacteralesDOI 10.1101/2023.11.16.567242
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