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Article

Inverse relationship between polygenic risk burden and age of onset of autoimmune vitiligo.

American journal of human genetics - 7 Nov 2024

Roberts Genevieve H L, Fain Pamela R, Santorico Stephanie A, Spritz Richard A

Abstract excerpt

Vitiligo is a common autoimmune disease characterized by patches of depigmented skin and overlying hair due to destruction of melanocytes in the involved regions. We investigated the relationship between vitiligo risk and vitiligo age of onset (AOO) using a vitiligo polygenic risk score that incorporated the most significant SNPs from genome-wide association studies. We find that vitiligo genetic risk and AOO are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39419028
DOI: 10.1016/j.ajhg.2024.09.007
PMCID: PMC11568747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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