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Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy

16 Oct 2024

Abstract excerpt

Synaptic damage is a crucial pathological process in traumatic brain injury. However, the mechanisms driving this process remain poorly understood. In this report, we demonstrate that the accumulation of damaged mitochondria, resulting from impaired mitphagy, plays a significant role in causing synaptic damage. Moreover, copper induced downregulation of BNIP3 is a key player in regulating mitophagy. DMSA...

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PMID: 39415457
DOI: 10.1080/15548627.2024.2409613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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