Article
Biallelic Loss of 7q34 (TRB) and 9p21.3 (CDKN2A/2B) in Adult Ph-Negative Acute T-Lymphoblastic Leukemia.
International journal of molecular sciences - 29 Sept 2024
Risinskaya Natalya, Abdulpatakhov Abdulpatakh, Chabaeva Yulia, Aleshina Olga, Gladysheva Maria, Nikulina Elena, Bolshakov Ivan, Yushkova Anna, Dubova Olga, Vasileva Anastasia, Obukhova Tatiana, Julhakyan Hunan, Kapranov Nikolay, Galtseva Irina, Kulikov Sergey, Sudarikov Andrey, Parovichnikova Elena
Abstract excerpt
Tumor cells of acute lymphoblastic leukemia (ALL) may have various genetic abnormalities. Some of them lead to a complete loss of certain genes. Our aim was to reveal biallelic deletions of genes in Ph-negative T-ALL. Chromosomal microarray analysis (CMA) was performed for 47 patients with de novo Ph-negative T-ALL, who received treatment according to RALL-2016m clinical protocol at the National Medical Research...
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