Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization.

doi:10.1016/j.jare.2024.03.015

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Article

Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization.

Journal of advanced research - 1 Mar 2025

Chang Kao-Jung, Wu Hsin-Yu, Chiang Pin-Hsuan, Hsu Yu-Tien, Weng Pei-Yu, Yu Ting-Han, Li Cheng-Yi, Chen Yu-Hsiang, Dai He-Jhen, Tsai Han-Ying, Chang Yu-Jung, Wu You-Ren, Yang Yi-Ping, Li Cheng-Ta, Hsu Chih-Chien, Chen Shih-Jen, Chen Yu-Chun, Cheng Ching-Yu, Hsieh Ai-Ru, Chiou Shih-Hwa

Abstract excerpt

INTRODUCTION: The clinical presentations of dry eye disease (DED) and depression (DEP) often comanifest. However, the robustness and the mechanisms underlying this association were undetermined. OBJECTIVES: To this end, we set up a three-segment study that employed multimodality results (meta-analysis, genome-wide association study [GWAS] and Mendelian randomization [MR]) to elucidate the association, common...

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PMID: 38548265
DOI: 10.1016/j.jare.2024.03.015
PMCID: PMC11954816

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