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Article

'Channeling' therapeutic discovery for epileptic encephalopathy through iPSC technologies.

Trends in pharmacological sciences - 1 May 2022

Simkin Dina, Ambrosi Christina, Marshall Kelly A, Williams Luis A, Eisenberg Jordyn, Gharib Mennat, Dempsey Graham T, George Alfred L, McManus Owen B, Kiskinis Evangelos

Abstract excerpt

Induced pluripotent stem cell (iPSC) and gene editing technologies have revolutionized the field of in vitro disease modeling, granting us access to disease-pertinent human cells of the central nervous system. These technologies are particularly well suited for the study of diseases with strong monogenic etiologies. Epilepsy is one of the most common neurological disorders in children, with approximately half of...

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Identifiers

PMID: 35427475
DOI: 10.1016/j.tips.2022.03.001
PMCID: PMC9119009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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