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Article

Effect of C-to-T transition at CpG sites on tumor suppressor genes in tumor development in cattle evaluated by somatic mutation analysis in enzootic bovine leukosis.

mSphere - 21 Nov 2024

Nishimori Asami, Andoh Kiyohiko, Matsuura Yuichi, Okagawa Tomohiro, Konnai Satoru

Abstract excerpt

Oncogenic transformation of normal cells is caused by mutations and chromosomal abnormalities in cancer-related genes. Enzootic bovine leukosis (EBL) is a malignant B-cell lymphoma caused by bovine leukemia virus (BLV) infection in cattle. Although a small fraction of BLV-infected cattle develops EBL after a long latent period, the mechanisms for oncogenesis in EBL cattle remain largely unknown. In this study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39404261
DOI: 10.1128/msphere.00216-24
PMCID: PMC11580432

Genes

TP53
CARD11
CREBBP
KMT2D
KRAS
MYD88
NOTCH1
PTEN

Provenance

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