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Article

A target enrichment high throughput sequencing system for characterization of BLV whole genome sequence, integration sites, clonality and host SNP.

Scientific reports - 25 Feb 2021

Ohnuki Nagaki, Kobayashi Tomoko, Matsuo Misaki, Nishikaku Kohei, Kusama Kazuya, Torii Yasushi, Inagaki Yasuko, Hori Masatoshi, Imakawa Kazuhiko, Satou Yorifumi

Abstract excerpt

Bovine leukemia virus (BLV) is an oncogenic retrovirus which induces malignant lymphoma termed enzootic bovine leukosis (EBL) after a long incubation period. Insertion sites of the BLV proviral genome as well as the associations between disease progression and polymorphisms of the virus and host genome are not fully understood. To characterize the biological coherence between virus and host, we developed a...

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Identifiers

PMID: 33633166
DOI: 10.1038/s41598-021-83909-3
PMCID: PMC7907107

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