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Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma

15 Oct 2015

Abstract excerpt

Endemic Burkitt lymphoma (eBL) is primarily found in children in equatorial regions and represents the first historical example of a virus-associated human malignancy. Although Epstein-Barr virus (EBV) infection and MYC translocations are hallmarks of the disease, it is unclear whether other factors may contribute to its development. We performed RNA-Seq on 20 eBL cases from Uganda and showed that the mutational...

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PMID: 26468873
DOI: 10.1371/journal.ppat.1005158

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