Article
Forensic STR and SNP Genotyping of Formalin-Fixed Skeleton Samples With Illumina's ForenSeq System.
Electrophoresis - 1 Nov 2024
Yang Tingting, Gao Linlin, Zhang Jiarong, Xie Wei, Hu Wenjing, Yan Jiangwei
Abstract excerpt
Formalin fixatives are widely used in forensics to preserve tissues. However, extracting high-quality genomic DNA from formalin-fixed samples is challenging. Traditional short tandem repeat (STR) analysis using capillary electrophoresis (CE) for forensic DNA typing frequently results in failure. Massively parallel sequencing (MPS) can handle many samples and thousands of genetic markers, usually single-nucleotide...
Topics
- Humans
- Polymorphism, Single Nucleotide
- Formaldehyde
- Microsatellite Repeats
- High-Throughput Nucleotide Sequencing
- Forensic Genetics
- Genotype
- DNA Fingerprinting
- Genotyping Techniques
- Bone and Bones