Article
The effectiveness of various strategies to improve DNA analysis of formaldehyde-damaged tissues from embalmed cadavers for human identification purposes.
Journal of forensic sciences - 1 Mar 2023
Czado Natalia, LaRue Bobby, Wheeler Amanda, Houston Rachel, Holmes Amy, Grisedale Kelly, Hughes Sheree
Abstract excerpt
Formalin-fixed tissues provide the medical and forensic communities with alternative and often last resort sources of DNA for identification or diagnostic purposes. The DNA in these samples can be highly degraded and chemically damaged, making downstream genotyping using short tandem repeats (STRs) challenging. Therefore, the use of alternative genetic markers, methods that pre-amplify the low amount of good...
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