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Article

Functional variant rs9344 at 11q13.3 regulates CCND1 expression in multiple myeloma with t(11;14).

Leukemia - 1 Jan 2025

Tang Hongwei, Yan Huihuang, Shivaram Suganti, Lehman Stacey, Sharma Neeraj, Smadbeck James, Zepeda-Mendoza Cinthya, Tian Shulan, Asmann Yan, Vachon Celine, Gaspar Maia Alexandre, Keats Jonathan, Bergsagel P Leif, Fonseca Rafael, Stewart A Keith, Hsu Joel-Sean, Kandasamy Richard K, Pandey Akhilesh, Kaddoura Marcella A, Maura Francesco, Mitra Amit, Rajkumar S Vincent, Kumar Shaji K, Elhaik Eran, Braggio Esteban, Baughn Linda B

Abstract excerpt

Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by cytogenetic abnormalities, such as t(11;14)(q13;q32), resulting in CCND1 overexpression. The rs9344 G allele within CCND1 is the most significant susceptibility allele for t(11;14). Sequencing data from 2 independent cohorts, CoMMpass (n = 698) and Mayo Clinic (n = 661), confirm the positive association between the G allele and t(11;14)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alleles

Share to Chromosomes, Human, Pair 11

Share to Chromosomes, Human, Pair 14

Share to Cyclin D1

Share to Gene Expression Regulation, Neoplastic

Share to Multiple Myeloma

Share to Polymorphism, Single Nucleotide

Share to Translocation, Genetic

Source

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Identifiers

PMID: 39402215
DOI: 10.1038/s41375-024-02363-y
PMCID: PMC11717701

Genes

CCND1
PAX5
PC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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