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Exploring the current molecular landscape and management of multiple myeloma patients with the t(11;14) translocation

2 Aug 2022

Abstract excerpt

Multiple myeloma (MM) is a genetically complex disease. The key myeloma-initiating genetic events are hyperdiploidy and translocations involving the immunoglobulin heavy chain (IgH) enhancer on chromosome 14, which leads to the activation of oncogenes (e.g., CCND1, CCND3, MAF, and MMSET). The t(11;14) translocation is the most common in MM (15%-20%) and results in cyclin D1 (CCND1) upregulation, which leads to...

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PMID: 35982976
DOI: 10.3389/fonc.2022.934008

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