The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

doi:10.1038/ng.2583

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Article

The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.

Nature genetics - 1 May 2013

Weinhold Niels, Johnson David C, Chubb Daniel, Chen Bowang, Försti Asta, Hosking Fay J, Broderick Peter, Ma Yussanne P, Dobbins Sara E, Hose Dirk, Walker Brian A, Davies Faith E, Kaiser Martin F, Li Ni L, Gregory Walter A, Jackson Graham H, Witzens-Harig Mathias, Neben Kai, Hoffmann Per, Nöthen Markus M, Mühleisen Thomas W, Eisele Lewin, Ross Fiona M, Jauch Anna, Goldschmidt Hartmut, Houlston Richard S, Morgan Gareth J, Hemminki Kari

Abstract excerpt

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly...

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PMID: 23502783
DOI: 10.1038/ng.2583
PMCID: PMC5056630

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CCND1

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