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Article

Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations

14 Oct 2024

Abstract excerpt

Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a pathophysiological pattern of gene expression. The downstream target genes that are activated by KLF2 are mostly unknown. Here we show that Chromobox Protein Homolog 7 (CBX7), component of the...

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Share to Epigenetics and DNA Methylation
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PMID: 39402138
DOI: 10.1038/s44321-024-00152-9

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