Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unveiling the shared genetic architecture between testosterone and polycystic ovary syndrome.

Scientific reports - 13 Oct 2024

Sun Shuliu, Liu Yan, Li Lanlan, Xiong Lili, Jiao Minjie, Yang Jian, Li Xiaojuan, Liu Wei

Abstract excerpt

Testosterone (T) is a critical predictor of polycystic ovary syndrome (PCOS) but the genetic overlap between T and PCOS has not been established. Here by leveraging genetic datasets from large-scale genome-wide association studies, we assessed the genetic correlation and polygenic overlap between PCOS and three T-related traits using linkage disequilibrium score regression and the bivariate causal mixture model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

Share to Multifactorial Inheritance

Share to Polycystic Ovary Syndrome

Share to Polymorphism, Single Nucleotide

Share to Sex Hormone-Binding Globulin

Share to Testosterone

Source

Open in PubMed Open full text

Identifiers

PMID: 39397165
DOI: 10.1038/s41598-024-75816-0
PMCID: PMC11471787

Genes

FSHB
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unveiling the shared genetic architecture between testosterone and polycystic ovary syndrome.PMID 39397165Read ↗

Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetesSemantic proximity Read ↗

Understanding and Predicting Polycystic Ovary Syndrome through Shared Genetics with Testosterone, SHBG, and Chronic InflammationSemantic proximity Read ↗

Colocalization highlights genes in hypothalamic–pituitary–gonadal axis as potentially mediating polycystic ovary syndrome riskSemantic proximity Read ↗

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic backgroundSemantic proximity Read ↗

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background.Semantic proximity Read ↗

Genetics of the polycystic ovary syndrome.Semantic proximity Read ↗

Colocalization analysis of polycystic ovary syndrome to identify potential disease-mediating genes and proteinsSemantic proximity Read ↗

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.Semantic proximity Read ↗

Large-Scale Genome-Wide Meta Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis CriteriaSemantic proximity Read ↗

Integrative Multi-omics Analysis for Prioritization of Candidate Genes in Polycystic Ovary Syndrome.Semantic proximity Read ↗

The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER+ breast cancer but not ER- breast cancerSemantic proximity Read ↗

Genetic analyses implicate complex links between adult testosterone levels and health and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.