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Article

Clinically-probed mechanisms of action in Fragile-X syndrome fail to normalize translational EEG phenotypes in Fmr1 knockout mice.

Neuropharmacology - 1 Jan 2025

Janz Philipp, Bainier Marie, Marashli Samuel, Gross Simon, Redondo Roger L

Abstract excerpt

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by Fragile X Messenger Ribonucleoprotein (FMRP) deficiency. Electroencephalogram (EEG) changes in FXS include alterations of oscillatory activity and responses to sensory stimuli, some of which have been back-translated into rodent models by knocking-out the Fragile X messenger ribonucleoprotein 1 gene (Fmr1-KO). However, the validity of these EEG...

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PMID: 39396738
DOI: 10.1016/j.neuropharm.2024.110182

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