Back to search

Article

Acute and chronic dosing of the GABA A alpha 2,3 selective agonist BAER-101 do not alter behavior but may impact auditory-evoked EEG responses in adults with fragile X syndrome

2025-12-16

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Fragile X syndrome (FXS) is characterized by sensory hypersensitivity and neural hyperexcitability linked to GABAergic dysfunction. BAER-101, formerly known as AZD7325, is a positive allosteric modulator of GABA <sub>A</sub> receptors with functional selectivity for α2/α3 subunits, designed to enhance inhibitory tone while minimizing sedation associated wit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c166421d-2188-537e-9353-28be2c088d32
DOI
10.21203/rs.3.rs-8123031/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Acute and chronic dosing of the GABA A alpha 2,3 selective agonist BAER-101 do not alter behavior but may impact auditory-evoked EEG responses in adults with fragile X syndromeDOI 10.21203/rs.3.rs-8123031/v1
Gaboxadol Increases Resting Theta and Alpha Power without Affecting Evoked Responses in Fragile X Syndrome in a Home-based SettingSemantic proximity
Clinically-probed mechanisms of action in Fragile-X syndrome fail to normalize translational EEG phenotypes in Fmr1 knockout mice.Semantic proximity
Auditory N1 event-related potential amplitude is predictive of serum concentration of BPN14770 in fragile x syndromeSemantic proximity
ROC Analysis of Biomarker Combinations in Fragile X Syndrome-Specific Clinical Trials: Evaluating Treatment Efficacy via Exploratory BiomarkersSemantic proximity
Increased aperiodic gamma power in young boys with Fragile X Syndrome is associated with better language abilitySemantic proximity
Increased aperiodic gamma power in young boys with Fragile X is associated with better language abilitySemantic proximity
Gamma spectral event power is elevated in Fragile X Syndrome and associated with single trial gamma power during auditory chirpSemantic proximity
Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome.Semantic proximity
Safety, Tolerability and EEG-Based Target Engagement of STP1 (PDE3,4 Inhibitor and NKCC1 Antagonist), in a Randomized Clinical Trial in a Subgroup of Patients with ASDSemantic proximity
Validating brain activity measures as reliable indicators of individual diagnostic group and genetically mediated sub-group membership Fragile X SyndromeSemantic proximity
Auditory steady-state response deficits in Fragile X Syndrome implicate deficits in stimulus representation maintenance and GABAergic modulationSemantic proximity
The selective 5-HT <sub>1A</sub> receptor biased agonist, NLX-101, corrects anomalous behavioral phenotype in a mouse model of Fragile X syndromeSemantic proximity
Select a neighboring publication to make it the new centre.