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Nexilin in cardiomyopathy: unveiling its diverse roles with special focus on endocardial fibroelastosis.

Heart failure reviews - 1 Sept 2024

Rahimzadeh Mahsa, Tennstedt Stephanie, Aherrahrou Zouhair

Abstract excerpt

Cardiac disorders exhibit considerable heterogeneity, and understanding their genetic foundations is crucial for their diagnosis and treatment. Recent genetic analyses involving a growing number of participants have uncovered novel mutations within both coding and non-coding regions of DNA, contributing to the onset of cardiac conditions. The NEXN gene, encoding the Nexilin protein, an actin filament-binding...

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PMID: 38985384
DOI: 10.1007/s10741-024-10416-8

Genes

NEXN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Nexilin in cardiomyopathy: unveiling its diverse roles with special focus on endocardial fibroelastosis.PMID 38985384Read ↗

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Unraveling the nexus of nesprin in dilated cardiomyopathy: From molecular insights to therapeutic prospects.Semantic proximity Read ↗

NEXN inhibits GATA4 and leads to atrial septal defects in mice and humans.Semantic proximity Read ↗

CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivoSemantic proximity Read ↗

Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.Semantic proximity Read ↗

Mutations in NEXN, a Z-disc gene, are associated with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Childhood onset nexilin dilated cardiomyopathy: A heterozygous and a homozygous case.Semantic proximity Read ↗

Homozygous G650del nexilin variant causes cardiomyopathy in mice.Semantic proximity Read ↗

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