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Article

IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis.

Communications biology - 19 Dec 2024

Wang Zhaoguo, Dai Dayou, Wang Siyao, Zhang Libo, Li Yi, Zhang Xunming, Cheng Yunyun, Hao Linlin

Abstract excerpt

Senile osteoporosis (SOP) is a multifactorial, age-related progressive phenomenon with a considerable morbidity and mortality. IGF-1 is an important regulator of bone reconstruction and metabolism throughout life. Nevertheless, our previous study unexpectedly found there is no change in the peak bone mass with a altered IGF-1 gene expression leaded by IGF-1 c.258 A > G synonymous mutation. Considering its...

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Identifiers

PMID: 39702559
DOI: 10.1038/s42003-024-07369-x
PMCID: PMC11659520

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