Article
Evolution of BA.2.86 to JN.1 reveals that functional changes in non-structural viral proteins are required for fitness of SARS-CoV-2.
Journal of virology - 23 Oct 2025
Tsujino Shuhei, Tsuda Masumi, Nao Naganori, Okumura Kaho, Wang Lei, Oda Yoshitaka, Mimura Yume, Li Jingshu, Hashimoto Rina, Matsumura Yasufumi, Suzuki Rigel, Suzuki Saori, Yoshimatsu Kumiko, Nagao Miki, Ito Jumpei, Takayama Kazuo, Sato Kei, Matsuno Keita, Tamura Tomokazu, Tanaka Shinya, Fukuhara Takasuke
Abstract excerpt
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is still circulating among humans, leading to the continuous evolution. SARS-CoV-2 Omicron JN.1 evolved from a distinct SARS-CoV-2 lineage, BA.2.86, and spread rapidly worldwide. It is unclear why BA.2.86 did not become dominant and was quickly replaced by JN.1, which possesses one amino acid...
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