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Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis

4 Aug 2023

Abstract excerpt

Background and Objectives In multiple sclerosis (MS), accelerated aging of the immune system (immunosenescence) may be associated with disease onset or drive progression. DNA methylation (DNAm) is an epigenetic factor that varies among lymphocyte subtypes, and cell-specific DNAm is associated with MS. DNAm varies across the life span and can be used to accurately estimate biological age acceleration, which has...

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PMID: 37541839
DOI: 10.1212/wnl.0000000000207489

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