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Sex differences in the molecular profile of adult diffuse glioma are shaped by IDH status and tumor microenvironment

5 Oct 2024

Abstract excerpt

BACKGROUND: Sex differences in adult diffuse glioma (ADG) are well established clinically, yet the underlying molecular mechanisms remain inadequately understood. Here, we aim to reveal molecular features and cellular compositions unique to each sex in ADG to comprehend the role of sex in disease etiology. METHODS: We quantified sex differences in the transcriptome of ADG using multiple independent glioma patient...

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PMID: 39367624
DOI: 10.1093/neuonc/noae207

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