Article
Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C.
Neuro-oncology - 26 Nov 2020
Eckel-Passow Jeanette E, Drucker Kristen L, Kollmeyer Thomas M, Kosel Matt L, Decker Paul A, Molinaro Annette M, Rice Terri, Praska Corinne E, Clark Lauren, Caron Alissa, Abyzov Alexej, Batzler Anthony, Song Jun S, Pekmezci Melike, Hansen Helen M, McCoy Lucie S, Bracci Paige M, Wiemels Joseph, Wiencke John K, Francis Stephen, Burns Terry C, Giannini Caterina, Lachance Daniel H, Wrensch Margaret, Jenkins Robert B
Abstract excerpt
BACKGROUND: Twenty-five germline variants are associated with adult diffuse glioma, and some of these variants have been shown to be associated with particular subtypes of glioma. We hypothesized that additional germline variants could be identified if a genome-wide association study (GWAS) were performed by molecular subtype. METHODS: A total of 1320 glioma cases and 1889 controls were used in the discovery set...
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