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Article

Identification of genomic features in environmentally induced epigenetic transgenerational inherited sperm epimutations.

PloS one - 1 Jan 2014

Guerrero-Bosagna Carlos, Weeks Shelby, Skinner Michael K

Abstract excerpt

A variety of environmental toxicants have been shown to induce the epigenetic transgenerational inheritance of disease and phenotypic variation. The process involves exposure of a gestating female and the developing fetus to environmental factors that promote permanent alterations in the epigenetic programming of the germline. The molecular aspects of the phenomenon involve epigenetic modifications (epimutations)...

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Identifiers

PMID: 24937757
DOI: 10.1371/journal.pone.0100194
PMCID: PMC4061094

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