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Trend of N86Y and Y184F Mutations in Pfmdr1 Gene in Children Under Seasonal Malaria Chemoprevention Coverage in Nanoro, Burkina Faso.

Acta parasitologica - 1 Dec 2024

Millogo Kié Solange, Kaboré Bérenger, Sondo Paul, Compaoré Eulalie W, Kouevi Amélé Fifi Chantal, Kambou Sié A Elisée, Rouamba Toussaint, Kazienga Adama, Ilboudo Hamidou, Tahita Marc Christian, Bouda Ismaila, Derra Karim, Bamba Sanata, Tinto Halidou

Abstract excerpt

BACKGROUND: Seasonal malaria chemoprevention (SMC) is an effective malaria preventive intervention in sub-Sahara Africa. However, as with any other drug-based intervention, the large-scale deployment of this strategy could lead to Amodiaquine plus Sulfadoxine-Pyrimethamine (AQSP) drug pressure on the circulating parasites population with selection for specific alleles that could compromise the impact of the...

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PMID: 39356425
DOI: 10.1007/s11686-024-00923-x
PMCID: PMC11649751

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