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Chronic stimulation desensitizes β2‐adrenergic receptor responses in natural killer cells

30 Sept 2024

Abstract excerpt

Adrenergic receptors (ARs) are preferentially expressed by innate lymphocytes such as natural killer (NK) cells. Here, we study the effect of epinephrine-mediated stimulation of the β2-adrenergic receptor (β2AR) on the function of human NK cells. Epinephrine stimulation inhibited early NK cell signaling events and blocked the function of the integrin LFA-1. This reduced the adhesion of NK cells to ICAM-1,...

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PMID: 39350450
DOI: 10.1002/eji.202451299

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