Genome-wide association studies for pelvic organ prolapse in the Japanese population.

doi:10.1038/s42003-024-06875-2

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Genome-wide association studies for pelvic organ prolapse in the Japanese population.

Communications biology - 30 Sept 2024

Matsunami Masatoshi, Imamura Minako, Ashikari Asuka, Liu Xiaoxi, Tomizuka Kohei, Hikino Keiko, Miwa Kosei, Kadekawa Katsumi, Suda Tetsuji, Matsuda Koichi, Miyazato Minoru, Terao Chikashi, Maeda Shiro

Abstract excerpt

Pelvic organ prolapse (POP) affects approximately 40% of elderly women, characterized by the descent of the pelvic organs into the vaginal cavity. Here we present the results of a genome-wide association study (GWAS) for susceptibility to POP comprising 771 cases and 76,625 controls in the Japanese population. We identified a significant association of WT1 locus with POP in the Japanese population; rs10742277;...

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Identifiers

PMID: 39349682
DOI: 10.1038/s42003-024-06875-2
PMCID: PMC11443051

Genes

FGFR2
WT1

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