Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-analyte approach combining cfDNA sequencing and protein testing for early ovarian cancer detection

9 May 2025

Abstract excerpt

Non-invasive liquid biopsy is a promising strategy for ovarian cancer (OC) detection. We evaluated the feasibility and efficacy of a multi-analyte approach combining circulating tumor DNA (ctDNA) detection with protein biomarkers for early OC detection. At 95% specificity, CA125 and ctDNA alone exhibited an overall sensitivity of 79.0% and 58.7%, respectively; however, when CA125 was combined with ctDNA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Molecular Biology Techniques and Applications
Share to Ovarian cancer diagnosis and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40502685
DOI: 10.1016/j.isci.2025.112617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-analyte approach combining cfDNA sequencing and protein testing for early ovarian cancer detectionPMID 40502685Read ↗

Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein BiomarkersSemantic proximity Read ↗

Multi-biomarker panel signature as the key to diagnosis of ovarian cancerSemantic proximity Read ↗

An overview of biomarkers for the ovarian cancer diagnosis.Semantic proximity Read ↗

Early and accurate detection of ovarian cancer by profiling cell-free mitochondrial DNA fragmentomics in multi-ethnic populationSemantic proximity Read ↗

Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)Semantic proximity Read ↗

Circulating Cell-Free DNA or Circulating Tumor DNA in the Management of Ovarian and Endometrial CancerSemantic proximity Read ↗

Advances in application of circulating tumor DNA in ovarian cancer.Semantic proximity Read ↗

Circulating tumor DNA: a noninvasive biomarker for tracking ovarian cancerSemantic proximity Read ↗

Plasma exosomal miRNA-205 can be used for early diagnosis and prognostic evaluation of ovarian cancerSemantic proximity Read ↗

Combining circulating tumor cell and circulating cell free DNA analyses enhances liquid biopsy sensitivity in detecting high grade serous tubo-ovarian carcinomaSemantic proximity Read ↗

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancerSemantic proximity Read ↗

High throughput proteomics identifies a high-accuracy 11 plasma protein biomarker signature for ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.