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The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection

10 Sept 2024

Abstract excerpt

/p62, hereafter referred to as p62) interferes with human cytomegalovirus (HCMV) infection. (2) Methods: CRISPR/Cas9-mediated genome editing, mass spectrometry and the expression of p62 phosphovariants from recombinant HCMVs were used to address the role of p62 during infection. (3) Results: The knockout of p62 resulted in an increased release of HCMV progeny. Mass spectrometry revealed an interaction of p62 with...

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PMID: 39339916
DOI: 10.3390/v16091440

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