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Article

Disulfide Bond Engineering of Soluble ACE2 for Thermal Stability Enhancement.

International journal of molecular sciences - 14 Sept 2024

Kim Yoon Soo, Kim Myeongbin, Park Hye Min, Kim Hyun Jin, Ryu Seong Eon

Abstract excerpt

Although the primary pandemic of SARS-CoV-2 is over, there are concerns about the resurgence of the next wave of related viruses, including a wide range of variant viruses. The soluble ACE2 (sACE2) inhibits the SARS-CoV-2 spike protein ACE2 interaction and has potential as a variant-independent therapeutic against SARS-CoV-2. Here, we introduce novel disulfide bonds in the wild-type sACE2-Fc by structure-guided...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39337407
DOI: 10.3390/ijms25189919
PMCID: PMC11432317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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