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Forward-reverse mutation cycles in cancer cell lines under chemical treatments.

Human genomics - 27 Sept 2024

Chen Si, Tyagi Iram S, Mat Wai Kin, Khan Muhammad A, Fan Weijian, Wu Zhenggang, Hu Taobo, Yang Can, Xue Hong

Abstract excerpt

Spontaneous forward-reverse mutations were reported by us earlier in clinical samples from various types of cancers and in HeLa cells under normal culture conditions. To investigate the effects of chemical stimulations on such mutation cycles, the present study examined single nucleotide variations (SNVs) and copy number variations (CNVs) in HeLa and A549 cells exposed to wogonin-containing or acidic medium. In...

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A549 Cells
Cell Line, Tumor
DNA Copy Number Variations
Flavanones
HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39334413
DOI: 10.1186/s40246-024-00661-1
PMCID: PMC11437743

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