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Article

Cellular Prion Protein Conformational Shift after Liquid-Liquid Phase Separation Regulated by a Polymeric Antagonist and Mutations.

Journal of the American Chemical Society - 9 Oct 2024

Liu Yangyi, Tuttle Marcus D, Kostylev Mikhail A, Roseman Graham P, Zilm Kurt W, Strittmatter Stephen M

Abstract excerpt

Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins has been associated with neurodegenerative diseases, although direct mechanisms are poorly defined. Here, we report on a maturation process for the cellular prion protein (PrPC) that involves a conformational change after LLPS and is regulated by mutations and poly(4-styrenesulfonic acid-co-maleic acid) (PSCMA), a molecule that has been...

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PMID: 39326869
DOI: 10.1021/jacs.4c10590
PMCID: PMC11469297

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