Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Serum-deprivation response of ARPE-19 cells; expression patterns relevant to age-related macular degeneration

26 Sept 2024

Abstract excerpt

ARPE-19 cells are derived from adult human retinal pigment epithelium (RPE). The response of these cells to the stress of serum deprivation mimics some important processes relevant to age-related macular degeneration (AMD). Here we extend the characterization of this response using RNASeq and EGSEA gene set analysis of ARPE-19 cells over nine days of serum deprivation. This experiment confirmed the up-regulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments
Share to Retinal Imaging and Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39325754
DOI: 10.1371/journal.pone.0293383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serum-deprivation response of ARPE-19 cells; expression patterns relevant to age-related macular degenerationPMID 39325754Read ↗

Serum-deprivation response of ARPE-19 cells; expression patterns relevant to age-related macular degenerationSemantic proximity Read ↗

Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degenerationSemantic proximity Read ↗

Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in<i>Abca4<sup>−/−</sup>Rdh8<sup>−/−</sup></i>Mice After Light ExposureSemantic proximity Read ↗

Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degenerationSemantic proximity Read ↗

Zinc supplementation induced transcriptional changes in primary human retinal pigment epithelium: a single-cell RNA sequencing study to understand age-related macular degenerationSemantic proximity Read ↗

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networksSemantic proximity Read ↗

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.Semantic proximity Read ↗

As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting TissuesSemantic proximity Read ↗

Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degenerationSemantic proximity Read ↗

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degenerationSemantic proximity Read ↗

RNA‐seq analysis of ageing human retinal pigment epithelium: Unexpected up‐regulation of visual cycle gene transcriptionSemantic proximity Read ↗

Senescence targeting re-enables injury-responsive repair in a human RPE aging modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.