Article
Amyloid-β1-43 cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations.
Alzheimer's research & therapy - 11 Sept 2020
Perrone Federica, Bjerke Maria, Hens Elisabeth, Sieben Anne, Timmers Maarten, De Roeck Arne, Vandenberghe Rik, Sleegers Kristel, Martin Jean-Jacques, De Deyn Peter P, Engelborghs Sebastiaan, van der Zee Julie, Van Broeckhoven Christine, Cacace Rita
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) mutations in amyloid precursor protein (APP) and presenilins (PSENs) could potentially lead to the production of longer amyloidogenic Aβ peptides. Amongst these, Aβ1-43 is more prone to aggregation and has higher toxic properties than the long-known Aβ1-42. However, a direct effect on Aβ1-43 in biomaterials of individuals carrying genetic mutations in the known AD genes is yet...
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