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Article

Cloning, expression and chromosomal mapping of human lysosomal sialidase and characterization of mutations in sialidosis.

Nature genetics - 1 Mar 1997

Pshezhetsky A V, Richard C, Michaud L, Igdoura S, Wang S, Elsliger M A, Qu J, Leclerc D, Gravel R, Dallaire L, Potier M

Abstract excerpt

Sialidase (neuraminidase, EC 3.2.1.18) catalyses the hydrolysis of terminal sialic acid residues of glyconjugates. Sialidase has been well studied in viruses and bacteria where it destroys the sialic acid-containing receptors at the surface of host cells, and mobilizes bacterial nutrients. In mammals, three types of sialidases, lysosomal, plasma membrane and cytosolic, have been described. For lysosomal sialidase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9054950
DOI: 10.1038/ng0397-316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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