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Article

M89V Sialic acid Acetyl Esterase (SIAE) and all other non-synonymous common variants of this gene are catalytically normal.

PloS one - 1 Jan 2013

Chellappa Vasant, Taylor Kendra N, Pedrick Kathryn, Donado Carlos, Netravali Ilka Arun, Haider Khaleda, Cariappa Annaiah, Dalomba Natasha F, Pillai Shiv

Abstract excerpt

Catalytically defective rare variants of Sialic acid Acetyl Esterase (SIAE) have previously been linked to autoimmunity. Studies presented here confirm that the M89V SIAE protein and all other products of common variant alleles of SIAE are catalytically normal. Although overexpressing transfected non-lymphoid cells secrete small amounts of SIAE that can associate with the cell surface, normal human lymphocytes do...

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Identifiers

PMID: 23308225
DOI: 10.1371/journal.pone.0053453
PMCID: PMC3538537

Genes

SIAE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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